Objective 

To evaluate the incidence, distribution, and course of squamous cell carcinoma (SCC) of the upper aerodigestive tract in patients infected with the human immunodeficiency virus (HIV) and compare it to SCC in non-HIV-infected patients.

Design 

Case-control study of all patients with SCC during 9.5-year period from January 1985 through June 1994.

Setting 

Two academic tertiary care centers in a metropolitan location.

Participants 

Five hundred thirty-nine patients (18 to 95 years old) with SCC of the upper aerodigestive tract.

Results 

Infection with HIV was present in 4.5% of the patients with SCC of the upper aerodigestive tract.

Patients infected with HIV were significantly younger than noninfected patients (P¾<. 001), accounting for 21.3% of those patients younger than 45 years (P<. 001).

No significant difference in tumor location was present between HIV-infected and noninfected patients ; however, HIV-infected patients had larger tumors (P=004) and a more advanced tumor stage (TNM classification) at presentation (P=05).

Tumor-related survival was significantly poorer in patients with HIV infection (P=01), with 57% at 1 year and 32% at 2 years, compared with 74% and 59%, for non-HIV-infected patients.

The detrimental effect of HIV infection on survival remained significant after adjusting for the confounding effects of age, tumor stage, and location of the tumor. (...)