Correlation of tumor markers p53, bcl-2, CD34, CD44H, CD44v6, and Ki-67 with survival and metastasis in laryngeal squamous cell carcinoma.
American Society of Head and Neck Surgery. Meeting. Palm Desert, Calif USA, 1995/05/01.
Recent basic discoveries about the biological significance of nuclear and cell-surface marker proteins have opened new areas of research into head and neck cancer.
However, the clinical significance of these markers is not yet understood.
To perform a historical prospective study of 70 patients with squamous cell carcinoma of the larynx who were treated at our institution between 1979 and 1989 to correlate tumor marker expression with survival and metastasis.
Archival tissue was immunohistochemically stained for the p53 tumor suppressor gene product, the inhibitor of apoptosis (bcl-2), the stem cell marker CD34, the cell adhesion molecules CD44H and CD44v6, and a marker of cellular proliferation (Ki-67).
The slides were examined using a light microscope and scored according to intensity and percentage of cells labeled.
The patients were stratified by tumor stage, and survival and metastatic data were correlated with staining scores.
For the stage IV group, increased expression of p53 and decreased expression of CD44H and CD44v6 correlated with a decreased survival (P=03, P=03, and P=02, respectively), and decreased expression of CD44H correlated with an increase in metastasis (P=01).
For all stages, excluding metastatic cases, increased p53 expression was consistent with a shorter survival (P<. 03), while increased CD44v6 expression was consistent with a longer survival (P<. 02). (...)
Mots-clés Pascal : Carcinome épidermoïde, Larynx, Homme, Pathogénie, Carcinogenèse, Marqueur tumoral, Pronostic, Protéine CAM, Adhérence, Métastase, Survie, Epidémiologie, Voie respiratoire supérieure, Tête cou, Tumeur maligne, ORL pathologie, Larynx pathologie
Mots-clés Pascal anglais : Squamous cell carcinoma, Larynx, Human, Pathogenesis, Carcinogenesis, Tumoral marker, Prognosis, Cell adhesion molecule, Adhesion, Metastasis, Survival, Epidemiology, Upper respiratory tract, Head and neck, Malignant tumor, ENT disease, Larynx disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0305230
Code Inist : 002B10B01. Création : 10/04/1997.