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  1. Lower gingival carcinoma : Clinical and pathologic determinants of regional metastases.

    Article - En anglais


    To determine which clinical and pathologic features are associated with regional metastases in patients with lower gingival squamous cell carcinoma.

    Patients and Methods 

    The medical charts of 155 previously untreated patients seen between 1970 and 1990 were retrospectively analyzed.

    All patients underwent surgical resection of the primary tumor.

    In addition, 66 patients underwent elective neck dissection, while a therapeutic neck dissection was performed in 28.

    Sixty-one patients who had clinically N0 neck disease did not undergo treatment of the cervical lymphatics.


    T stage (P=01), radiologic (P=03) or histologic (P=01) evidence of mandibular invasion, and decreased tumor differentiation (P=004) significantly correlated with the presence or evolution of regional metastases.

    In addition, tumors involving the symphyseal region were associated with an increased incidence of nodal metastases, although the relationship did not achieve statistical significance (P=08).

    Occult regional disease was found in 18% of patients who underwent elective neck dissection, and the presence of metastases was pathologically confirmed in 68% who underwent a therapeutic dissection.

    Six patients with clinically N0 neck disease did not undergo elective dissection and later developed regional metastases.

    In all patients, survival was adversely impacted by the presence or later development of regional metastases (P<. 001). (...)

    Mots-clés Pascal : Carcinome épidermoïde, Gencive, Homme, Facteur risque, Métastase, Pronostic, Traitement, Adénopathie, Survie, Epidémiologie, Ganglion lymphatique, Tête cou, Stomatologie, Cavité buccale pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Squamous cell carcinoma, Gingiva, Human, Risk factor, Metastasis, Prognosis, Treatment, Adenopathy, Survival, Epidemiology, Lymph node, Head and neck, Stomatology, Oral cavity disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0305097

    Code Inist : 002B10C01. Création : 10/04/1997.