logo BDSP

Base documentaire


  1. Fulltext. Age-related changes in total and high-density-lipoprotein cholesterol in elderly Dutch men.

    Article - En anglais

    Fulltext.

    Objectives

    This study investigated changes in total and high-density-lipoprotein cholesterol (HDL) concentrations with age and time in elderly men.

    Methods

    A cohort of men born between 1900 and 1920 from the Dutch town of Zutphen was examined in 1977 and 1978 (n=571), 1985 (n=885), 1990 (n=555), and 1993 (n=345).

    Linear regression analysis and random-effects models were used to assess cross-sectional and longitudinal age-and time-related changes in cholesterol concentrations.

    Results

    In both cross-sectional and longitudinal analyses, total cholesterol decreased by 0.04 mmol/L a year with age.

    The longitudinal change was observed in the entire population as well as in men who participated in all four examinations (n=135) and in a subgroup of men who were free of common chronic diseases, were not on cholesterol : lowering medication or a prescribed diet, and rated themselves as being « healthy » (n=64).

    HDL cholesterol did note change significantly with age neither on a cross-sectional nor on a longitudinal basis.

    Conclusions

    Among elderly men, total cholesterol diminishes with age both on a cross-sectional and on a longitudinal basis ; HDL cholesterol does not vary with age in any way.

    Mots-clés Pascal : Lipoprotéine HDL, Cholestérol HDL, Lipide, Epidémiologie, Vieillard, Homme, Age, Etude longitudinale, Etude transversale, Pays Bas, Europe

    Mots-clés Pascal anglais : Lipoprotein HDL, Cholesterol HDL, Lipids, Epidemiology, Elderly, Human, Age, Follow up study, Cross sectional study, Netherlands, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0300049

    Code Inist : 002B29A. Création : 199608.