This study investigated changes in total and high-density-lipoprotein cholesterol (HDL) concentrations with age and time in elderly men.
A cohort of men born between 1900 and 1920 from the Dutch town of Zutphen was examined in 1977 and 1978 (n=571), 1985 (n=885), 1990 (n=555), and 1993 (n=345).
Linear regression analysis and random-effects models were used to assess cross-sectional and longitudinal age-and time-related changes in cholesterol concentrations.
In both cross-sectional and longitudinal analyses, total cholesterol decreased by 0.04 mmol/L a year with age.
The longitudinal change was observed in the entire population as well as in men who participated in all four examinations (n=135) and in a subgroup of men who were free of common chronic diseases, were not on cholesterol : lowering medication or a prescribed diet, and rated themselves as being « healthy » (n=64).
HDL cholesterol did note change significantly with age neither on a cross-sectional nor on a longitudinal basis.
Among elderly men, total cholesterol diminishes with age both on a cross-sectional and on a longitudinal basis ; HDL cholesterol does not vary with age in any way.
Mots-clés Pascal : Lipoprotéine HDL, Cholestérol HDL, Lipide, Epidémiologie, Vieillard, Homme, Age, Etude longitudinale, Etude transversale, Pays Bas, Europe
Mots-clés Pascal anglais : Lipoprotein HDL, Cholesterol HDL, Lipids, Epidemiology, Elderly, Human, Age, Follow up study, Cross sectional study, Netherlands, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0300049
Code Inist : 002B29A. Création : 199608.