Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites : The insulin resistance atherosclerosis study.
The etiology of NIDDM is still controversial, with both insulin resistance and decreased insulin secretion postulated as potential important factors.
African-Americans and Hispanics have a two-to threefold excess risk of developing NIDDM compared with non-Hispanic whites.
Yet little is known concerning the prevalence of insulin resistance and secretion defects in minorities, especially in African-Americans in population-based studies.
Fasting and 2-h post-glucose load glucose and insulin levels, insulin-mediated glucose disposal (insulin sensitivity index) (S,), glucose effectiveness (SG), and first-phase insulin response (acute insulin response [AIR]) were determined in nondiabetic African-Americans (n=288), Hispanics (n=363), and non-Hispanic whites (n=435) as part of the Insulin Resistance Atherosclerosis Study.
Subjects received a standard 2-h oral glucose tolerance test on the first day and an insulin-modified frequently sampled intravenous glucose tolerance test on the second day.
African-Americans and Hispanics were more obese than non-Hispanic whites.
Both African-Americans and Hispanics had higher fasting and 2-h insulin concentrations and AIR but lower S, than non-Hispanic whites.
No ethnic difference was observed in SG.
After further adjustments for obesity, body fat distribution, and behavioral factors, African-Americans continued to have higher fasting and 2-h insulin levels and AIR, but lower S, than non-Hispanic whites.
In contrast, after ad...
Mots-clés Pascal : Résistance tissu cible, Insuline, Sécrétion endocrine, Noir américain, Latinoaméricain, Caucasoïde, Athérosclérose, Diabète non insulinodépendant, Hormone pancréatique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Endocrinopathie, Homme, Epidémiologie
Mots-clés Pascal anglais : Target tissue resistance, Insulin, Endocrine secretion, Black American, Latinamerican, Caucasoid, Atherosclerosis, Non insulin dependent diabetes, Pancreatic hormone, Cardiovascular disease, Vascular disease, Endocrinopathy, Human, Epidemiology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0297971
Code Inist : 002B30A01A2. Création : 199608.