Characterization of acute lymphoblastic leukemia subtypes in Brazilian patients.
The distribution of the acute lymphoblastic leukemia (ALL) subsets in 225 consecutive Brazilian patients was determined by an immunophenotypic study with an extensive panel of monoclonal antibodies.
All subsets were detected and their relative frequencies were similar to those described in developed countries, except for the B-mature subset which had a higher frequency, especially in adults.
Associated myeloid markers were expressed by 11% of the ALL and CD10 by 15.9% of T-ALL cases.
Besides, the incidence rates determined for the region of Ribeirao Preto showed that the overall incidence of ALL was 12.5 cases/106 people years (PY) (5 cases/106 PY in non-Whites versus 14 cases/106 PY in Whites) ; the incidence of childhood ALL was 25.5 cases/106 PY (8.1 versus 29.8 cases/106 PY in non-Whites and Whites, respectively) and the incidence of ALL in adults was 6.2 cases/106 PY (5.5 versus 6.1 cases/106 PY in non-Whites and Whites, respectively).
The significantly lower incidence rate of ALL in non-White children was associated with a selective deficit of the common subtype and a lack of the typical age peak of incidence in this group.
The ALL features demonstrated here in Brazilian non-White children resemble those described in the American non-Whites before the seventies and those in British and American Whites at the beginning of the century.
Mots-clés Pascal : Leucémie lymphoblastique, Homme, Incidence, Epidémiologie, Ethnie, Phénotype, Cytologie, Age, Brésil, Amérique du Sud, Amérique, Echelon régional, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Human, Incidence, Epidemiology, Ethnic group, Phenotype, Cytology, Age, Brazil, South America, America, Regional scope, Acute, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0296894
Code Inist : 002B19B. Création : 199608.