Objectives-To examine the cancer risk of shoe manufacturing workers and evaluate whether the risk was associated with exposure to leather dust and solvents.
Method-Data from two historical cohort studies of shoe workers were expanded and analysed in parallel.
A total of 4215 shoemakers from England contributing 103 726 person-years at risk and 2008 shoemakers from Florence, Italy, contributing 54 395 person-years at risk were included in the analysis.
Exposure to leather dusts and solvents from glues was evaluated on the basis of job title information.
Standardised mortality ratios (SMR) were calculated as ratios of observed deaths (Obs) over expected derived from national mortalities.
Overall mortality was lower than expected in both cohorts (English cohort : Obs 3314, SMR 81,95% confidence interval (95% CI) 78-84 ; Florence cohort : Obs 333, SMR 87,95% CI 78-97).
An increased risk of nasal cancer was found (English cohort : Obs 12, SMR 741 ; Florence cohort : Obs 1, SMR 909). 10 of the 13 cases occurred among English workers employed in the manufacture of welted boots (SMR 926,95% CI 444-1703), a sector of the industry thought to have had the highest exposure to leather dust.
Mortality from leukaemia was not increased in the English cohort (Obs 16, SMR 89), but was increased in the Florence cohort (Obs 8, SMR 214,95% CI 92-421) ; and the highest risk was found among shoe workers in Florence who were first exposed between 1950 and 1959 when exposu...
Mots-clés Pascal : Tumeur maligne, Nez, Leucémie, Industrie cuir, Chaussure, Poussière, Cuir, Solvant organique, Benzène, Exposition professionnelle, Epidémiologie, Mortalité, Médecine travail, Homme, ORL pathologie, Nez pathologie, Hémopathie maligne, Angleterre, Grande Bretagne, Royaume Uni, Europe, Italie, Toxicité
Mots-clés Pascal anglais : Malignant tumor, Nose, Leukemia, Leather industry, Shoe, Dust, Leather, Organic solvent, Benzene, Occupational exposure, Epidemiology, Mortality, Occupational medicine, Human, ENT disease, Nose disease, Malignant hemopathy, England, Great Britain, United Kingdom, Europe, Italy, Toxicity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0295640
Code Inist : 002B04B. Création : 199608.