Aim-To investigate the association of human immunodeficiency virus (HIV) infection and carcinoma of the conjunctiva in Africa, and the role of human papilloma virus type 16 (HPV-16).
Methods-Patients in Uganda and Malawi presenting to eye clinics with lesions suspicious of carcinoma were studied.
Pathological confirmation of eye lesions was sought.
HIV testing of patients who were biopsied and, in Uganda, of matched case control subjects was carried out as was testing of a sample of fixed biopsies for HPV-16 by polymerase chain reaction (PCR).
The HIV-1 serology, histopathology of conjunctival biopsies (conjunctival intraepithelial neoplasia (CIN), invasive carcinoma, other lesions), and prevalence of HPV-16 infection were determined.
Of Ugandan patients, 27138 (71%) with carcinoma (27 invasive carcinoma, 11 CIN) were HIV positive compared with 12176 (16%) of controls (odds ratio 13,95% confidence interval 5-38).
The calculated population aetiological fraction of carcinoma associated with HIV was 66%. Of 32 Malawian patients (20 invasive carcinoma, 12 CIN), 25129 tested (86%) were HIV positive.
HPV-16 infection was found in 7120 (35%) of carcinoma samples, 019 pingueculae, and 216 conjunctivitis samples.
Conclusions-HIV infection is strongly associated with an apparent increase in the incidence of conjunctival carcinoma in Africa.
While ultraviolet light is probably the prime risk factor and HPV-16 is implicated in a proportion of cases, the intera...
Mots-clés Pascal : SIDA, Virose, Infection, Carcinome, Conjonctive, Ouganda, Afrique, Malawi, Epidémiologie, Rayonnement UV, Papillomavirus humain 16, Papillomavirus, Papovaviridae, Virus, Pathogénie, Association, Homme, Immunopathologie, Immunodéficit, Tumeur maligne, Oeil pathologie, Conjonctive pathologie
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Carcinoma, Conjunctiva, Uganda, Africa, Malawi, Epidemiology, Ultraviolet radiation, Human papillomavirus 16, Papillomavirus, Papovaviridae, Virus, Pathogenesis, Association, Human, Immunopathology, Immune deficiency, Malignant tumor, Eye disease, Conjunctiva disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0293996
Code Inist : 002B06D01. Création : 199608.