There is consistent evidence that the risk of neural tube defects is decreased by periconceptional supplementation with folic acid.
A similar protective effect has been postulated for oral clefts.
A case-control study was conducted in greater metropolitan Boston, Massachusetts ; Philadelphia, Pennsylvania ; and southeastern Ontario, Canada, from 1988 through 1991 to test the hypothesis that folic acid supplementation during the periconceptional period reduces the risk of oral clefts.
Crude and multivariate-adjusted relative risks were calculated for all oral clefts (n=303), cleft palate (n=108), and cleft lip with or without cleft palate (n=195).
Controls (n=1,167) were liveborn or stillborn infants less than age 6 months who had various congenital anomalies other than oral clefts, neural tube defects, or other « midline defects. » Adjusted relative risks and 95 percent confidence intervals for daily folic acid supplementation during the periconceptional period were : oral clefts, 1.1 (95% confidence interval (CI) 0.8-1.7), cleft palate, 0.9 (95% CI 0.5-1.6), and cleft lip with or without cleft palate, 1.3 (95% CI 0.8-2.1).
These findings do not support a protective association between the periconceptional use of folic acid supplements and the risk of oral clefts.
Mots-clés Pascal : Gestation, Régime alimentaire enrichi, Folate, Fissure congénitale, Lèvre, Palais, Supplémentation, Vitamine, Epidémiologie, Prévention, Evaluation, Etats Unis, Amérique du Nord, Amérique, Face, Stomatologie, Cavité buccale pathologie, Maladie congénitale, Malformation
Mots-clés Pascal anglais : Pregnancy, Supplemented diet, Folate, Cleft, Lip, Palate, Supplementation, Vitamin, Epidemiology, Prevention, Evaluation, United States, North America, America, Face, Stomatology, Oral cavity disease, Congenital disease, Malformation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0293957
Code Inist : 002B20F02. Création : 199608.