Workers in plants producing carbon anodes for aluminium electrolysis are exposed to PAHs containing coal tar pitch volatiles, pitch and coke.
The aim of this study was to evaluate the suitability of urinary 1-hydroxypyrene to characterize respiratory exposure to PAH, which is most relevant for assessing individual health risks.
Six workers in a carbon anode plant volunteered to take part in a personal air sampling and a biological monitoring programme lasting five consecutive 8-h shifts to determine occupational exposure to airborne PAHs and urinary excretion of 1-hydroxypyrene.
Exposure to total PAH for all worksites varied from 3.99 to 120.6 mug PAH m-3 and for benzo (a) pyrene (BaP) from 0.17 to 4.88 mug BaP m-3.
The concentration of 1-hydroxypyrene in post-and pre-shift urine samples was in the range (0.5-61.8 mumol 1-OHP per mol creatinine) and depended on the worksite.
The Spearman rank correlation test showed a low but significant (P<0.05) correlation of urinary 1-hydroxypyrene in the post-and pre-shift samples with respiratory pyrene exposure.
The quantitative aspects of biological monitoring for the evaluation of respiratory PAH exposure were tested with a pharmacokinetic model.
On the basis of individual pyrene exposure, excretion of urinary 1-hydroxypyrene during the working week was calculated for each worker.
The results presented in this investigation indicate that biological monitoring of the pyrene metabolite 1-hydroxypyrene is a useful ind...
Mots-clés Pascal : Composé aromatique polycyclique, Inhalation, Exposition professionnelle, Homme, Surveillance biologique, Métabolite, Urine, Teneur air ambiant, Analyse chimique, Contrôle, Lieu travail, Toxicocinétique, Médecine travail, Anode carbone
Mots-clés Pascal anglais : Polycyclic aromatic compound, Inhalation, Occupational exposure, Human, Biological monitoring, Metabolite, Urine, Ambient air concentration, Chemical analysis, Check, Work place, Toxicokinetics, Occupational medicine
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0289326
Code Inist : 002B03L06. Création : 199608.