Necropsy study of the association between sudden cardiac death, cardiac isoenzymes and contraction band necrosis.
Aims-To assess whether a quantitative analysis of myocardial contraction bands could aid the postmortem identification of early myocardial infarction, especially if used in conjunction with cardiac isoenzyme activities.
Methods-Sixty four coroner's necropsies were grouped by gross and histological findings into 26 cases of definite non-cardiac death, 12 cases of definite myocardial infarction and 26 cases in which there was occlusive coronary artery atheroma, but no demonstrable evidence of infarction.
Using multiple sections of left ventricular myocardium stained with Heidenhain's iron haematoxylin, the number of myocardial cells containing contraction bands per unit area was quantified.
The results were analysed statistically using logistic regression, and were then compared and combined with results from the statistical analysis of postmortem cardiac isoenzymes that had recently been undertaken on the same cases.
The number of cells containing contraction bands per unit area was higher in cases of definite myocardial infarction compared with those of non-cardiac deaths.
In addition, cases of occlusive coronary artery atheroma only could be identified, indicating the presence of early myocardial infarction.
The accuracy of this identification could be improved by combining these results with the results from the statistical analysis of postmortem cardiac isoenzymes.
Conclusion-The quantitative assessment of myocardial contraction band necrosis ca...
Mots-clés Pascal : Infarctus, Myocarde, Mort subite, Anatomopathologie, Nécrose, Contraction, Bande, Isozyme, Coeur, Médecine légale, Diagnostic, Homme, Autopsie, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Infarct, Myocardium, Sudden death, Pathology, Necrosis, Contraction, Strip, Isozyme, Heart, Legal medicine, Diagnosis, Human, Autopsy, Cardiovascular disease, Coronary heart disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0279879
Code Inist : 002B30A11. Création : 199608.