Objectives-To assess further the relation in Intersalt of 24 hour urinary sodium to blood pressure of individuals and populations, and the difference in blood pressure from young adulthood into middle age.
Design-Standardised cross sectional study within and across populations.
Subjects-10 074 men and women aged 20-59.
Main outcome measure-Association of sodium and blood pressure from within population and cross population multiple linear regression analyses with multivariate correction for regression dilution bias.
Relation of sample median daily urinary sodium excretion to difference in blood pressure with age.
In within population analyses (n=10 074), individual 24 hour urinary sodium excretion higher by 100 mmol (for example, 170 v 70 mmol) was associated with systolic/diastolic blood pressure higher on average by 310 to 6/3 mm Hg (with and without body mass in analyses).
Associations were larger at ages 40-59.
In cross population analyses (n=52), sample median 24 hour sodium excretion higher by 100 mmol was associated with median systolic/diastolic pressure higher on average by 5-7/2-4 mm Hg, and estimated mean difference in systolicldiastolic pressure at age 55 compared with age 25 greater by 10-11/6 mm Hg.
Conclusions-The strong, positive association of urinary sodium with systolic pressure of individuals concurs with Intersalt cross population findings and results of other studies.
Mots-clés Pascal : Corrélation, Taux concentration, Sodium, Urine, Pression sanguine, Exploration clinique, Evolution, Age, Ethnie, Etude cohorte, Homme, Appareil urinaire, Appareil circulatoire, Etude Intersalt
Mots-clés Pascal anglais : Correlation, Concentration factor, Sodium, Urine, Blood pressure, Clinical investigation, Evolution, Age, Ethnic group, Cohort study, Human, Urinary system, Circulatory system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0279778
Code Inist : 002B12B05B. Création : 199608.