Porokeratosis and cutaneous malignancy : A review.
Porokeratosis is a disorder of epidermal keratinization manifested clinically by a raised border and histologically by a cornoid lamella.
While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown.
In the past it has been associated with a history of radiation therapy.
The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk.
All cases in the English language literature in the last 30 years were reviewed.
Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis.
Large lesions, those of long-standing duration, and the linear type were at greatest risk.
Radiation therapy was an infrequently identified risk factor.
Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation.
Mots-clés Pascal : Porokératose, Facteur risque, Transformation maligne, Prédisposition, Caractérisation, Epidémiologie, Revue bibliographique, Homme, Peau pathologie, Dyskératose, Hyperkératose
Mots-clés Pascal anglais : Porokeratosis, Risk factor, Malignant transformation, Predisposition, Characterization, Epidemiology, Bibliographic review, Human, Skin disease, Dyskeratosis, Hyperkeratosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0278310
Code Inist : 002B08I. Création : 199608.