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  1. Porokeratosis and cutaneous malignancy : A review.

    Article - En anglais

    BACKGROUND

    Porokeratosis is a disorder of epidermal keratinization manifested clinically by a raised border and histologically by a cornoid lamella.

    While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown.

    In the past it has been associated with a history of radiation therapy.

    OBJECTIVE

    The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk.

    METHODS

    All cases in the English language literature in the last 30 years were reviewed.

    RESULTS

    Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis.

    Large lesions, those of long-standing duration, and the linear type were at greatest risk.

    Radiation therapy was an infrequently identified risk factor.

    CONCLUSION

    Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation.

    Mots-clés Pascal : Porokératose, Facteur risque, Transformation maligne, Prédisposition, Caractérisation, Epidémiologie, Revue bibliographique, Homme, Peau pathologie, Dyskératose, Hyperkératose

    Mots-clés Pascal anglais : Porokeratosis, Risk factor, Malignant transformation, Predisposition, Characterization, Epidemiology, Bibliographic review, Human, Skin disease, Dyskeratosis, Hyperkeratosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0278310

    Code Inist : 002B08I. Création : 199608.