This article examines the credibility and policy implications of the « amphibole hypothesis, » which postulates that (1) the mesotheliomas observed among workers exposed to chrysotile asbestos may be explained by confounding exposures to amphiboles, and (2) chrysotile may have lower carcinogenic potency than amphiboles.
A critical review was conducted of the lung burden, epidemiologic, toxicologic, and mechanistic studies that provide the basis for the amphibole hypothesis.
Mechanistic and lung burden studies do not provide convincing evidence for the amphibole hypothesis.
Toxicologic and epidemiologic studies provide strong evidence that chrysotile is associated with an increased risk of lung cancer and mesothelioma.
Chrysotile may be less potent than some amphiboles for inducing mesotheliomas, but there is little evidence to indicate lower lung cancer risk.
Given the evidence of a significant lung cancer risk, the lack of conclusive evidence for the amphibole hypothesis, and the fact that workers are generally exposed to a mixture of fibers, we conclude that it is prudent to treat chrysotile with virtually the same level of concern as the amphibole forms of asbestos.
Mots-clés Pascal : Chrysotile, Fibre amiante, Exposition professionnelle, Mésothéliome, Bronchopulmonaire, Carcinogène, Toxicité, Amphibole, Etude critique, Epidémiologie, Homme, Médecine travail, Tumeur maligne, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Asbestos fiber, Occupational exposure, Mesothelioma, Bronchopulmonary, Carcinogen, Toxicity, Amphibole, Critical study, Epidemiology, Human, Occupational medicine, Malignant tumor, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0276357
Code Inist : 002B04B. Création : 199608.