Established risk factors cannot explain all the variance in coronary heart disease (CHD).
Immunoglobin E (IgE), a mediator of allergy, can affect platelets and arterial smooth muscle.
We previously demonstrated a cross-sectional association between IgE and cardiovascular disease (CVD) in men.
The present study evaluated this relationship prospectively in 278 men and 343 women followed for a mean of 8.9 years.
There was an association between IgE and coronary disease in men, but not in women.
There was no association for CVD, stroke, or all-cause mortality.
The age-adjusted relative risk (RR) for coronary mortality in men with baseline IgE = 200 kU/L was 1.66 (p¾0.66), but for nonfatal myocardial infarction (MI) it was 6.46 (p¾0.01).
This association was independent of smoking and other risk factors, and unrelated to allergy.
Thus, elevated IgE was a strong independent prospective risk factor for nonfatal, but not fatal, MI in men.
Mots-clés Pascal : Infarctus, Myocarde, Facteur risque, IgE, Prédiction, Homme, Epidémiologie, Sexe, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Infarct, Myocardium, Risk factor, IgE, Prediction, Human, Epidemiology, Sex, United States, North America, America, Cardiovascular disease, Coronary heart disease, Myocardial disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0276014
Code Inist : 002B12A03. Création : 199608.