Substantial lack of consensus exists regarding the appropriate management of patients with locally advanced non-small cell lung cancer (NSCLC).
The purpose of the present study was to investigate why published clinical trials have not resolved this uncertainty, and to examine the potential of current randomized studies to resolve the major controversies regarding the treatment of locally advanced NSCLC.
A literature search identified papers addressing the therapy of locally advanced NSCLC published in the English language from January 1966 through March 1993.
The treatment modalities studied in these trials were recorded.
The CD-ROM Physician Data Query database was used to identify ongoing studies in NSCLC.
For phase III trials in stage III NSCLC, the treatment modalities, eligibility criteria, outcome measures, and statistical considerations were recorded.
A total of 164 reports of phase III trials were identified, representing 11% of the 1516 publications meeting search criteria.
A wide range of comparisons have been reported ; the number of study arms, the number of different modalities employed as control arms, and the number of modalities employed as investigational arms increased over time.
Eighteen active phase III protocols open to patients with stage III NSCLC were identified.
In trials which enrolled patients with stage IIIB disease, therapy in control arms employed six different strategies of surgery, radiation, or...
Mots-clés Pascal : Carcinome non petite cellule, Bronchopulmonaire, Etude comparative, Essai clinique phase III, Traitement, Homme, Recherche appliquée, Modalité traitement, Synthèse bibliographique, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne
Mots-clés Pascal anglais : Non small cell carcinoma, Bronchopulmonary, Comparative study, Phase III trial, Treatment, Human, Applied research, Application method, Bibliographic survey, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0275812
Code Inist : 002B11A. Création : 199608.