logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Locally advanced non-small cell lung cancer : Do we know the questions ? A survey of randomized trials from 1966-1993.

    Article - En anglais

    Background

    Substantial lack of consensus exists regarding the appropriate management of patients with locally advanced non-small cell lung cancer (NSCLC).

    The purpose of the present study was to investigate why published clinical trials have not resolved this uncertainty, and to examine the potential of current randomized studies to resolve the major controversies regarding the treatment of locally advanced NSCLC.

    Methods

    A literature search identified papers addressing the therapy of locally advanced NSCLC published in the English language from January 1966 through March 1993.

    The treatment modalities studied in these trials were recorded.

    The CD-ROM Physician Data Query database was used to identify ongoing studies in NSCLC.

    For phase III trials in stage III NSCLC, the treatment modalities, eligibility criteria, outcome measures, and statistical considerations were recorded.

    Results

    A total of 164 reports of phase III trials were identified, representing 11% of the 1516 publications meeting search criteria.

    A wide range of comparisons have been reported ; the number of study arms, the number of different modalities employed as control arms, and the number of modalities employed as investigational arms increased over time.

    Eighteen active phase III protocols open to patients with stage III NSCLC were identified.

    In trials which enrolled patients with stage IIIB disease, therapy in control arms employed six different strategies of surgery, radiation, or...

    Mots-clés Pascal : Carcinome non petite cellule, Bronchopulmonaire, Etude comparative, Essai clinique phase III, Traitement, Homme, Recherche appliquée, Modalité traitement, Synthèse bibliographique, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Non small cell carcinoma, Bronchopulmonary, Comparative study, Phase III trial, Treatment, Human, Applied research, Application method, Bibliographic survey, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0275812

    Code Inist : 002B11A. Création : 199608.