To study maternal smoking during pregnancy and the risk of congenital urinary tract anomalies, we interviewed mothers of 118 affected infants born to residents of western Washington State during 1990 and 1991 and mothers of 369 control infants randomly selected from those without birth defects delivered during those years in five hospitals in King Country, Washington, Maternal smoking was associated with an increased risk of congenital urinary tract anomalies in offspring (adjusted odds ratio [OR]=2.3 ; 95% confidence interval [CI]=1.2,4.5).
This risk was higher among light smokers (1-1000 cigarettes during the pregnancy) (OR=3.7 ; 95% CI=1.7,8.6) than among heavy smokers (OR=1.4 ; 95% CI=0.6,3.3).
Our results corroborate previous findings and support the hypothesis of a causal relation.
Mots-clés Pascal : Malformation, Voie urinaire, Toxicité, Tabagisme, Tératogène, Gestation, Mère, Nourrisson, Homme, Epidémiologie, Washington, Etats Unis, Amérique du Nord, Amérique, Voie urinaire pathologie, Appareil urinaire pathologie
Mots-clés Pascal anglais : Malformation, Urinary tract, Toxicity, Tobacco smoking, Teratogen, Pregnancy, Mother, Infant, Human, Epidemiology, Washington, United States, North America, America, Urinary tract disease, Urinary system disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0275654
Code Inist : 002B03E. Création : 199608.