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  1. Fulltext. Genetic screening for reproductive planning : Methodological and conceptual issues in policy analysis.

    Article - En anglais

    Fulltext.

    Objectives

    This paper explores several critical assumptions and methodological issues arising in cost-effectiveness analyses of genetic screening strategies in the reproductive setting.

    Methods

    Seven issues that arose in the development of a decision analysis of alternative strategies for cystic fibrosis carrier screening are discussed.

    Each of these issues required a choice in technique.

    Results

    The presentations of these analyses frequently mask underlying assumptions and methodological choices.

    Often there is no best choice.

    In the case of genetic screening in the reproductive setting, these underlying issues often touch on deeply felt human values.

    Conclusions

    Space limitations for published paper often preclude explaining such choices in detail ; yet these decisions determine the way the results should be interpreted.

    Those who develop these analyses need to make sure that the implications of important assumptions are understood by the clinicians who will use them.

    At the same time, clinicians need to enhance their understanding of what these models truly mean and how they address underlying clinical, ethical, and economic issues.

    Mots-clés Pascal : Mucoviscidose, Dépistage, Stratégie, Analyse décision, Analyse coût efficacité, Economie santé, Homme, Prénatal, Parent, Appareil respiratoire pathologie, Appareil digestif pathologie, Pancréas pathologie, Maladie héréditaire, Métabolisme pathologie

    Mots-clés Pascal anglais : Cystic fibrosis, Medical screening, Strategy, Decision analysis, Cost efficiency analysis, Health economy, Human, Prenatal, Parent, Respiratory disease, Digestive diseases, Pancreatic disease, Genetic disease, Metabolic diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0273299

    Code Inist : 002B30A03B. Création : 199608.