Tumour development, histology and grade of breast cancers : prognosis and progression.
Using 1,973 breast tumours from women aged 40-69 participating in the Swedish two-county trial of mammographic screening for breast cancer, we examined the effect of histological type on prognosis and sojourn time (the duration of the preclinical screen-detectable phase) by age.
The hypothesis of dedifferentiation, according to which a cancer of mixed malignancy grade drifts towards grade 3 as the more poorly differentiated part of the tumour grows faster than the well-differentiated part, was also assessed.
Ductal carcinoma in situ, invasive ductal carcinoma of grade 1, mucinous carcinoma and tubular carcinoma were all associated with good survival.
Ductal carcinoma of grade 3 was associated with poor survival.
Ductal carcinoma of grade 2, lobular and medullary carcinoma were associated with intermediate survival.
These patterns were much the same in women aged 40-49 as in women aged 50-69.
In women aged 40-49, sojourn time was estimated at about 2 years regardless of histological type.
For women aged 50-69, there was a marked association of sojourn time with histological type, the shortest sojourn time being observed for lobular (2 years) and medullary (1.2 years) carcinoma, and the longest for ductal carcinoma grade 1 (7.7 years) and tubular carcinoma (7.1 years).
There was strong evidence of a potential to dedifferentiation.
A mover-stayer mixture of Markov chain models estimated that, in women aged 40-54,91% of ductal tumours have the potential to ded...
Mots-clés Pascal : Carcinome, Glande mammaire, Pronostic, Survie, Histopathologie, Type histologique, Grade histologique, Homme, Age, Epidémiologie, Différenciation, Tumeur maligne, Glande mammaire pathologie, Anatomopathologie
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Prognosis, Survival, Histopathology, Histological type, Histological grading, Human, Age, Epidemiology, Differentiation, Malignant tumor, Mammary gland diseases, Pathology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0273134
Code Inist : 002B20E02. Création : 199608.