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  1. Perinatal HIV infection and the effect of zidovudine therapy on transmission in rural and urban counties.

    Article - En anglais


    - To assess health care providers'identification of human immunodeficiency virus (HIV) - exposed infants, to ascertain the prevalence of transplacental or oral zidovudine treatment among infants exposed to HIV, and to estimate the impact of zidovudine use on perinatal transmission in rural and urban North Carolina.


    - Survey of North Carolina newboms tested for HIV infection in 1993 and 1994 compared with the number of anonymous HIV-positive childbearing women.


    - North Carolina hospitals, public health clinics, and private physicians'offices.

    Main Outcome Measures

    - Rates of identification of HIV-exposed infants and of perinatal HIV-1 transmission, determined by HIV culture and polymerase chain reaction testing in the infants.


    - The proportion of HIV-exposed children in North Carolina who were identified and tested increased from 60% in 1993 to 82% for all of 1994, and to more than 90% for the last quarter of 1994.

    The HIV-exposed infants born in rural counties were more likely to be recognized than those born in urban counties (P<. 001).

    In 1994, most infants were evaluated relatively early in life : 39% by 1 week of age, 63% by 6 weeks, and 76% by 3 months.

    Among infants with recognized HIV exposure, transmission decreased significantly between 1993 and 1994, from 21% to 8.5%, respectively (P=009).

    After the announcement of the results of AIDS Clinical Trials Group Protocol 076, zidovudine was given to 75% of HIV-pos...

    Mots-clés Pascal : SIDA, Virose, Infection, Zidovudine, Antiviral, Chimiothérapie, Transmission mère enfant, Périnatal, Gestation, Milieu urbain, Milieu rural, Etude comparative, Prévention, Epidémiologie, Traitement, Nourrisson, Homme, Nouveau né, Caroline du Nord, Etats Unis, Amérique du Nord, Amérique, Voie orale, Pyrimidine nucléoside, Mère, Immunopathologie, Immunodéficit, Gestation pathologie

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Antiviral, Chemotherapy, Mother to child transmission, Perinatal, Pregnancy, Urban environment, Rural environment, Comparative study, Prevention, Epidemiology, Treatment, Infant, Human, Newborn, North Carolina, United States, North America, America, Oral administration, Pyrimidine nucleoside, Mother, Immunopathology, Immune deficiency, Pregnancy disorders

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0272091

    Code Inist : 002B06D01. Création : 199608.