The role of diet in the aetiology of renal cell carcinoma was investigated in a population-based case-control study in Denmark.
Cases were 20-79 years old, with a histologically verified diagnosis of renal cell carcinoma.
Controls were sampled from the general population and were frequency-matched on age and sex.
A total of 351 cases (73% ofthe eligible) and 340 controls (68% ofthe eligible) were included in the study.
Dietary information was obtained in a self-administered food frequency questionaire and the information was confirmed in a subsequent interview performed by trained interviewers who also elicited information on other suspected risk factors such as smoking, occupation, medical history, education and reproductive history.
Logistic regression models were used to calculate the odds ratios, and, both frequency of consumption of various food stuffs and computed nutrients were examined.
A positive association was observed between risk of renal cell carcinoma and total energy intake (odds ratio, OR, for highest quartile compared to lowest : 1.7 (95% confidence interval, CI, 1.0-3.0) for men, and 3.5 (95% CI 1.6-6.5) for women), fat intake (OR for highest quartile compared to lowest : 1.9 (95% CI 1.1-3.5) for men, and 3.3 (95% CI 1.6-6.9) for women).
For women, an effect was also seen for intake of carbohydrates (OR for highest quartile compared to lowest : 3.2 (95% CI 1.5-6.8), while no protective effect was seen for vegetables or fruit.
Mots-clés Pascal : Hypernéphrome, Homme, Facteur risque, Epidémiologie, Danemark, Europe, Alimentation, Nutrition, Carcinome, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne
Mots-clés Pascal anglais : Grawitz tumor, Human, Risk factor, Epidemiology, Denmark, Europe, Feeding, Nutrition, Carcinoma, Urinary system disease, Renal disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0264411
Code Inist : 002B14D01. Création : 199608.