Family history of breast cancer is an established risk factor for this disease and is used to identify women at higher risk, although the impact of risk factors for breast cancer among women with a family history is not well defined.
Using a modified extended log-incidence Pike model, we prospectively examined the impact of risk factors for breast cancer among women with and without a family history of the disease.
Data analyzed were obtained prospectively from the Nurses'Health Study.
Two thousand two hundred forty-nine incident cases of invasive breast cancer were identified in a cohort of 89 132 women aged 30-55 years in 1976 followed biennially through 1990 (1.1 million person-years of follow-up).
With the use of proportional hazards models, we evaluated the association between risk factors for breast cancer and risk among women with and those without a family history of the disease.
We then fit a modified extended log-incidence Pike model to these data.
Among women with a family history of breast cancer, reproductive risk factors had associations that were different from those observed among women without a family history of the disease.
In particular, we observed little protection from later age at menarche, no protection from multiple births when compared with nulliparity, nor from early, as compared with later, age at first birth.
Fitting these data to a model of breast cancer incidence on the basis of rep...
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Antécédent, Histoire familiale, Epidémiologie, Modèle mathématique, Etats Unis, Amérique du Nord, Amérique, Homme, Glande mammaire pathologie, Génie biomédical
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Antecedent, Family story, Epidemiology, Mathematical model, United States, North America, America, Human, Mammary gland diseases, Biomedical engineering
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0262039
Code Inist : 002B20E02. Création : 199608.