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  1. Pathway to a paradigm : The linear nonthreshold dose-response model in historical context : The American Academy of Health Physics 1995 radiology centennal Hartman oration.

    Article - En anglais

    This paper traces the evolution of the linear nonthreshold dose-response model and its acceptance as a paradigm in radiation protection practice and risk analysis.

    Deterministic effects such as skin burns and even deep tissue trauma were associated with excessive exposure to x rays shortly after their discovery, and carcinogenicity was observed as early as 1902.

    Still, it was not until 1925 that the first protective limits were suggested.

    For three decades these limits were based on the concept of a tolerance dose which, if not exceeded, would result in no demonstrable harm to the individual and implicitly assumed a threshold dose below which radiation effects would be absent.

    After World War II, largely because of genetic concerns related to atmospheric weapons testing, radiation protection dose limits were expressed in terms of a risk based maximum permissible dose which clearly implied no threshold.

    The 1927 discovery by Muller of x-ray induced genetic mutations in fruit flies, linear with dose and with no apparent threshold, was an important underpinning of the standards.

    The linear nonthreshold dose-response model was originally used to provide an upper limit estimate of the risk, with zero being the lower limit, of low level irradiation since the dose-response curve could not be determined at low dose levels.

    Evidence to the contrary such as hormesis and the classic studies of the radium dial painters notwithstanding, the linear nonthreshold model ga...

    Mots-clés Pascal : Radioactivité, Article synthèse, Historique, Radiolésion, Modèle non linéaire, Relation dose réponse, Analyse risque, Dose limite, Norme sécurité, Rayon X, Dose rayonnement, Dosimétrie

    Mots-clés Pascal anglais : Radioactivity, Review, Case history, Radiation injury, Non linear model, Dose activity relation, Risk analysis, Limit dose, Safety standard, X ray, Radiation dose, Dosimetry

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0260267

    Code Inist : 002A08F03. Création : 199608.