Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort.
To describe the incidence and prognosis of wheezing illness from birth to age 33 and the relation of incidence to perinatal, medical, social, environmental, and lifestyle factors.
Design-Prospective longitudinal study
Setting-England, Scotland, and Wales.
Subjects-18 559 people born on 3-9 March 1958.
5801 (31%) contributed information at ages 7,11,16,23, and 33 years.
Attrition bias was evaluated using information on 14 571 (79%) subjects.
Main outcome measure-History of asthma, wheezy bronchitis, or wheezing obtained from interview with subjects'parents at ages 7,11, and 16 and reported at interview by subjects at ages 23 and 33.
The cumulative incidence of wheezing illness was 18% by age 7,24% by age 16, and 43% by age 33.
Incidence during childhood was strongly and independently associated with pneumonia, hay fever, and eczema.
There were weaker independent associations with male sex, third trimester antepartum haemorrhage, whooping cough, recurrent abdominal pain, and migraine.
Incidence from age 17 to 33 was associated strongly with active cigarette smoking and a history of hay fever.
There were weaker independent associations with female sex, maternal albuminuria during pregnancy, and histories of eczema and migraine.
Maternal smoking during pregnancy was weakly and inconsistently related to childhood wheezing but was a stronger and significant independent predictor of incidence after age 16.
Among 880 subjects who developed asthm...
Mots-clés Pascal : Asthme, Allergie, Tabagisme, Grande Bretagne, Royaume Uni, Europe, Epidémiologie, Pronostic, Enfant, Homme, Adulte jeune, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie
Mots-clés Pascal anglais : Asthma, Allergy, Tobacco smoking, Great Britain, United Kingdom, Europe, Epidemiology, Prognosis, Child, Human, Young adult, Respiratory disease, Obstructive pulmonary disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0258679
Code Inist : 002B06C02. Création : 199608.