Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer.
Individuals who had cancer in childhood are at higher risk of developing bone cancer than any other type of second primary cancer.
Using the population-based National Registry of Childhood Tumours in Britain, we investigated the incidence and etiology of second primary bone cancer after childhood cancer in a cohort study and in a case-control study.
A cohort study of 13 175 3-year survivors of childhood cancer diagnosed in Britain between 1940 and 1983 revealed 55 subsequent bone cancers.
A largely nested case-control study comprised 59 case subjects developing second primary bone cancer, and 220 control subjects were selected and matched for sex, type of first cancer, age at first cancer, and interval between diagnosis of first cancer and subsequent bone cancer.
Outcome measures were the incidence of bone cancer after childhood cancer, the cumulative dose of radiation received at the site of the second bone cancer in the case subject and at the corresponding anatomic site in the matched control subjects, and the cumulative dose of alkylating agents and vinca alkaloids received by case and control subjects.
The percentage of 3-year survivors developing bone cancer within 20 years did not exceed 0.9%, except following heritable retinoblastoma (7.2%), Ewing's sarcoma (5.4%), and other malignant bone tumors (2.4%). The risk of bone cancer increased substantially with increased cumulative dose of radiation to the bone...
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Enfant, Homme, Second cancer, Os, Epidémiologie, Incidence, Etiologie, Anticancéreux, Toxicité, Radiothérapie, Etude cohorte, Agent alkylant, Système ostéoarticulaire pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Child, Human, Second cancer, Bone, Epidemiology, Incidence, Etiology, Antineoplastic agent, Toxicity, Radiotherapy, Cohort study, Alkylating agent, Diseases of the osteoarticular system, Case control study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0257649
Code Inist : 002B04C. Création : 199608.