The objective of this study was to identify occupational exposures that might be etiologically linked to an unusual cluster of ten cases of Hodgkin's disease.
The cases were identified within the active workforce of a large chemical manufacturing firm over a 23-year period by the medical director of the facilities.
Based on comparison with regional cancer incidence rates, the standardized incidence ratio for Hodgkin's disease was 497 (95% confidence interval : 238-915) for the period from the construction of the facilities in 1966 through early 1992.
A nested case-control study was undertaken with 200 controls selected according to case-cohort sampling.
Simultaneously, efforts were initiated to confirm and characterize each case more fully.
Occupational exposures were identified and categorized using process, work history, medical record, and industrial hygiene data.
Tissue slides were available for eight cases and a second review confirmed the diagnosis of Hodgkin's disease.
For one case, a final diagnosis of large-cell anaplastic lymphoma was determined after histology review.
Among 214 different chemical agents studied, eight were identified to which three or more of the cases had been exposed prior to the date of their initial diagnosis.
Exposure odds ratios were statistically elevated for five of these agents ; dose-response evaluations for two of the agents, ethylene oxide and benzene, failed to provide additional support for a causal relationship.
Mots-clés Pascal : Hodgkin maladie, Exposition professionnelle, Médecine travail, Industrie chimique, Etiologie, Homme, Epidémiologie, Pays Bas, Europe, Hémopathie maligne, Lymphoprolifératif syndrome, Lymphome
Mots-clés Pascal anglais : Hodgkin disease, Occupational exposure, Occupational medicine, Chemical industry, Etiology, Human, Epidemiology, Netherlands, Europe, Malignant hemopathy, Lymphoproliferative syndrome, Lymphoma
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0257125
Code Inist : 002B19B. Création : 199608.