Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damages office environment.
There is growing concern about adverse health effects of fungal bio-aerosols on occupants of water-damaged buildings.
Accidental, occupational exposure in a nonagricultural setting has not been investigated using modern immunological laboratory tests.
The objective of this study was to evaluate the health status of office workers after exposure to fungal bio-aerosols, especially Stachybotrys chartarum (atra) (S. chartarum) and its toxigenic metabolites (satratoxins), and to study laboratory parameters or biomarkers related to allergic or toxic human health effects.
Exposure characterization and quantification were performed using microscopic, culture, and chemical techniques.
The study population (n=53) consisted of 39 female and 14 male employees (mean age 34.8 years) who had worked for a mean of 3.1 years at a problem office site ; a control group comprised 21 persons (mean age 37.5 years) without contact with the problem office site.
Health complaints were surveyed with a 187-item standardized questionnaire.
A comprehensive test battery was used to study the red and white blood cell system, serum chemistry, immunology/antibodies, lymphocyte enumeration and function.
Widespread fungal contamination of water-damaged, primarily cellulose material with S. chartarum was found.
S. chartarum produced a macrocyclic trichothecene, satratoxin H, and spirocyclic lactones.
Strong associations with exposure indicators and significant differences between employees (n...
Mots-clés Pascal : Stachybotrys chartarum, Fungi Imperfecti, Fungi, Thallophyta, Mycotoxine, Exposition professionnelle, Toxicité, Médecine travail, Réponse immune, Immunopathologie, Aérosol, Homme, Marqueur biologique, Exploration, Bureau, Humidité, Moisissure
Mots-clés Pascal anglais : Stachybotrys chartarum, Fungi Imperfecti, Fungi, Thallophyta, Mycotoxin, Occupational exposure, Toxicity, Occupational medicine, Immune response, Immunopathology, Aerosols, Human, Biological marker, Exploration, Office, Humidity, Mould
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0257124
Code Inist : 002B03J. Création : 199608.