Prospective study of serum micronutrients and ovarian cancer.
Antioxidant micronutrients, such as alpha-tocopherol (vitamin E), the carotenoids, and selenium, may protect against the development of cancer by preventing free radical damage at the cellular level.
A nested case-control study was conducted among donors to a serum bank to examine the association between levels of serum micronutrients and/or cholesterol and the development of ovarian cancer.
In 1974, sera were collected from 20 305 residents of Washington County, MD, over a 4-month period and stored at - 70 °C. Serum micronutrient concentrations of women who developed ovarian cancer (case subjects, n=35) were compared with those of women who remained free of cancer and who were matched to case subjects on age and menopausal status (control subjects, n=67).
Serum levels of retinol (vitamin A), alpha-and bêta-carotene (the major provitamin A), lycopene (a carotenoid), and alpha-and gamma-tocopherol were measured using high-performance liquid chromatography.
Serum selenium was measured by neutron activation analysis.
Cholesterol was measured by enzymatic assay
The data were categorized into thirds and conditional logistic regression analyses were performed to determine the association between prediagnostic serum cholesterol and micronutrient levels and the development of ovarian cancer ; matched odds ratios (ORs) were determined from these regression analyses.
P values for trend and for interaction were calculated with the us...
Mots-clés Pascal : Tumeur maligne, Ovaire, Homme, Analyse risque, Epidémiologie, alpha-Tocophérol, Caroténoïde, Sélénium, Cholestérol, Rétinol, Sérum, Concentration, Exploration, Micronutriment, Antioxydant, Appareil génital femelle pathologie, Ovaire pathologie, Vitamine, Lipide, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Ovary, Human, Risk analysis, Epidemiology, alpha-Tocopherol, Carotenoid, Selenium, Cholesterol, Retinol, Serum, Concentration, Exploration, Micronutrient, Antioxidant, Female genital diseases, Ovarian diseases, Vitamin, Lipids, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0256981
Code Inist : 002B20C02. Création : 199608.