Although some evidence indicates that early detection protects against the development of lethal melanoma, no randomized clinical trials have been conducted to measure the efficacy of early detection (or screening) in preventing death from this disease.
Since melanoma incidence in the United States is relatively rare, a randomized clinical trial to test the efficacy of screening would be extremely expensive.
As an alternative to a randomized clinical trial, we conducted a population-based, case-control study to investigate whether early detection through skin self-examination (SSE) is associated with a decreased risk of lethal melanoma (includes the presence of advanced disease with distant metastases in addition to death from melanoma).
SSE (conducting a careful, deliberate, and purposeful examination of the skin) was assessed in all subjects by use of a structured questionnaire and personal interviews.
The major exposure variable, SSE, was defined following focus-group interviews with melanoma patients and healthy control subjects.
The final study population consisted of 1199 Caucasian residents of the state of Connecticut enrolled from January 15,1987, through May 15,1989 ; 650 individuals were newly diagnosed with cutaneous melanoma, and the remaining 549 individuals were age-and sex-frequency matched control subjects from the general population.
During the study interviews, nevi on the arms and backs of subjects were c...
Mots-clés Pascal : Mélanome malin, Peau, Dépistage, Stade précoce, Epidémiologie, Prévention, Homme, Efficacité, Tumeur maligne, Peau pathologie, Autoexamen, Etude cas témoin
Mots-clés Pascal anglais : Malignant melanoma, Skin, Medical screening, Early stage, Epidemiology, Prevention, Human, Efficiency, Malignant tumor, Skin disease, Case control study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0256966
Code Inist : 002B08A. Création : 199608.