The epidemiology of neuroblastoma suggests that prenatal exposures may be important etiologic factors in this disease.
The authors describe the role of maternal health status and prenatal medication usage and risk of neuroblastoma.
This retrospective study was based on completed interviews with 183 histologically confirmed neuroblastoma cases aged 0-14 years diagnosed among residents of New York State (excluding New York City) between 1976 and 1987.
Controls were matched to cases on year of birth and race and were drawn from the New York State live birth certificate registry.
Interviews were satisfactorily completed with 85% of the cases and 87% of controls.
Significantly elevated odds ratios were noted for vaginal infections during pregnancy (odds ratio (OR)=2.2,95% confidence interval (CI) 1.2-4.0), medical treatments for vaginal infection during pregnancy (OR=2.4,95% CI 1.2-4.9), and any reported use of sex hormones during pregnancy (OR=3.0,95% CI 1.3-6.9).
Point estimates for any hormone use suggested elevated risk among male offspring (OR=4.4,95% CI 1.5-13.3).
Among the individual exposures comprising any hormone use, only hormone use related to infertility was observed to be significant (OR=10.4,95% CI 1.2-89.9).
A protective effect was noted for self-reported vitamin use (OR=0.28,95% CI 0.03-0.69).
Although it is not possible to presume a specific role for prenatal hormone exposure as initiator or promoter, these findings lend support to an associat...
Mots-clés Pascal : Neuroblastome, Epidémiologie, Enfant, Homme, Santé, Mère, Gestation, Chimiothérapie, Médicament, Hormone stéroïde sexuelle, Traitement, New York, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux sympathique pathologie, Tumeur maligne
Mots-clés Pascal anglais : Neuroblastoma, Epidemiology, Child, Human, Health, Mother, Pregnancy, Chemotherapy, Drug, Sex steroid hormone, Treatment, New York, United States, North America, America, Nervous system diseases, Autonomic neuropathy, Malignant tumor
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0254463
Code Inist : 002B17E. Création : 199608.