To examine the associations between intakes of calcium, vitamin D, and dairy foods and the risk of colon cancer, the authors analyzed data from a prospective study of 47,935 US male health professionals, 40-75 years of age and free of cancer in 1986.
Within this cohort, 203 new cases of colon cancer were documented between 1986 and 1992.
After adjusting for age and total energy intake, the authors found that the intake of calcium from foods and supplements was inversely associated with colon cancer risk (relative risk (RR)=0.58,95% confidence interval (CI) 0.39-0.87 between high and low intakes of calcium).
However, after adjusting for confounding variables, they found that the trend was no longer statistically significant (p=0.22), and the relative risk for the highest quintile group of intake was attenuated : 0.75 (95% CI 0.48-1.15).
Similar results were observed for total vitamin D intake ; the age-and energy-adjusted relative risk was 0.54 (95% CI 0.34-0.85) for the highest versus lowest quintile group, and this was attenuated in the multivariate model (RR=0.66,95% CI 0.42-1.05).
The inverse association was weaker for dietary vitamin D (RR for highest vs. lowest quintile=0.88,95% CI 0.54-1.42) and strongest for vitamin D arising from vitamin supplements (RR=0.48,95% CI 0.22-1.02).
Thus, it is possible that other components of multivitamin use rather than vitamin D accounted for the reduction in risk.
Consumption of milk and fermented dairy products was...
Mots-clés Pascal : Calcium, Vitamine D, Produit laitier, Tumeur maligne, Côlon, Régime alimentaire enrichi, Consommation alimentaire, Epidémiologie, Homme, Chimiothérapie, Traitement, Comportement alimentaire, Etats Unis, Amérique du Nord, Amérique, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie
Mots-clés Pascal anglais : Calcium, Vitamin D, Dairy product, Malignant tumor, Colon, Supplemented diet, Food intake, Epidemiology, Human, Chemotherapy, Treatment, Feeding behavior, United States, North America, America, Digestive diseases, Intestinal disease, Colonic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0254310
Code Inist : 002B13B01. Création : 199608.