The role of dietary antioxidant vitamins in preventing coronary heart disease has aroused considerable interest because of the knowledge that oxidative modification of low-density lipoprotein may promote atherosclerosis.
We studied 34,486 postmenopausal women with no cardiovascular disease who in early 1986 completed a questionnaire that assessed, among other factors, their intake of vitamins A, E, and C from food sources and supplements.
During approximately seven years of follow-up (ending December 31,1992), 242 of the women died of coronary heart disease.
In analyses adjusted for age and dietary energy intake, vitamin E consumption appeared to be inversely associated with the risk of death from coronary heart disease.
This association was particularly striking in the subgroup of 21,809 women who did not consume vitamin supplements (relative risks from lowest to highest quintile of vitamin E intake, 1.0,0.68,0.71,0.42, and 0.42 ; P for trend=0.008).
After adjustment for possible confounding variables, this inverse association remained (relative risks from lowest to highest quintile, 1.0,0.70,0.76,0.32, and 0.38 ; P for trend=0.004).
There was little evidence that the intake of vitamin E from supplements was associated with a decreased risk of death from coronary heart disease, but the effects of high-dose supplementation and the duration of supplement use could not be definitively addressed.
Intake of vitamins A and C did no...
Mots-clés Pascal : Cardiopathie coronaire, Athérosclérose, Ménopause, Lipoprotéine LDL, Antioxydant, alpha-Tocophérol, Régime alimentaire enrichi, Epidémiologie, Etude longitudinale, Exploration, Prévention, Mortalité, Adulte, Femelle, Etats Unis, Homme, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Analyse biochimique
Mots-clés Pascal anglais : Coronary heart disease, Atherosclerosis, Menopause, Lipoprotein LDL, Antioxidant, alpha-Tocopherol, Supplemented diet, Epidemiology, Follow up study, Exploration, Prevention, Mortality, Adult, Female, United States, Human, North America, America, Cardiovascular disease, Vascular disease, Biochemical analysis
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0250125
Code Inist : 002B30A01A2. Création : 199608.