Lung cancer and cardiovascular disease are major causes of death in the United States.
It has been proposed that carotenoids and retinoids are agents that may prevent these disorders.
We conducted a multicenter, randomized, double-blind, placebo-controlled primary prevention trial - the Beta-Carotene and Retinol Efficacy Trial - involving a total of 18,314 smokers, former smokers, and workers exposed to asbestos.
The effects of a combination of 30 mg of beta carotene per day and 25,000 IU of retinol (vitamin A) in the form of retinyl palmitate per day on the primary end point, the incidence of lung cancer, were compared with those of placebo.
A total of 388 new cases of lung cancer were diagnosed during the 73,135 person-years of follow-up (mean length of follow-up, 4.0 years).
The active-treatment group had a relative risk of lung cancer of 1.28 (95 percent confidence interval, 1.04 to 1.57 ; P=0.02), as compared with the placebo group.
There were no statistically significant differences in the risks of other types of cancer.
In the active-treatment group, the relative risk of death from any cause was 1.17 (95 percent confidence interval, 1.03 to 1.33) ; of death from lung cancer, 1.46 (95 percent confidence interval, 1.07 to 2.00) ; and of death from cardiovascular disease, 1.26 (95 percent confidence interval, 0.99 to 1.61).
On the basis of these findings, the randomized trial was stopped 21 months earlier than planned ; fo...
Mots-clés Pascal : Adénocarcinome, Bronchopulmonaire, Athérosclérose, Régime alimentaire enrichi, Carotène, Rétinol, Epidémiologie, Etats Unis, Prévention, Mortalité, Adulte, Mâle, Etude longitudinale, Amérique du Nord, Amérique, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Adenocarcinoma, Bronchopulmonary, Atherosclerosis, Supplemented diet, Carotene, Retinol, Epidemiology, United States, Prevention, Mortality, Adult, Male, Follow up study, North America, America, Human, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0250124
Code Inist : 002B30A01A2. Création : 199608.