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  1. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.

    Article - En anglais


    Observational studies suggest that people who consume more fruits and vegetables containing beta carotene have somewhat lower risks of cancer and cardiovascular disease, and earlier basic research suggested plausible mechanisms.

    Because large randomized trials of long duration were necessary to test this hypothesis directly, we conducted a trial of beta carotene supplementation.


    In a randomized, double-blind, placebo-controlled trial of beta carotene (50 mg on alternate days), we enrolled 22,071 male physicians, 40 to 84 years of age, in the United States ; 11 percent were current smokers and 39 percent were former smokers at the beginning of the study in 1982.

    By December 31,1995, the scheduled end of the study, fewer than 1 percent had been lost to follow-up, and compliance was 78 percent in the group that received beta carotene.


    Among 11,036 physicians randomly assigned to receive beta carotene and 11,035 assigned to receive placebo, there were virtually no early or late differences in the overall incidence of malignant neoplasms or cardiovascular disease, or in overall mortality.

    In the beta carotene group, 1273 men had any malignant neoplasm (except nonmelanoma skin cancer), as compared with 1293 in the placebo group (relative risk, 0.98 ; 95 percent confidence interval, 0.91 to 1.06).

    There were also no significant differences in the number of cases of lung cancer (82 in the beta carotene group vs. 88 in the placebo grou...

    Mots-clés Pascal : Tumeur maligne, Athérosclérose, Régime alimentaire enrichi, Carotène, Alimentation, Epidémiologie, Etude longitudinale, Prévention, Mortalité, Homme, Mâle, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie

    Mots-clés Pascal anglais : Malignant tumor, Atherosclerosis, Supplemented diet, Carotene, Feeding, Epidemiology, Follow up study, Prevention, Mortality, Human, Male, United States, North America, America, Cardiovascular disease, Vascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0250123

    Code Inist : 002B30A01A2. Création : 199608.