This Belgian study assessed the geographical and temporal differences in the exposure of the population to inorganic arsenic, a known carcinogen.
Methods-In the CadmiBel study (1985-9) the 24 h urinary arsenic excretion was measured, as an index of recent exposure, in industrialised cities (Liège : n=664, Charleroi : n=291), in a rural control area (Hechtel-Eksel : n=397), and in rural districts in which the population had possibly been exposed through the drinking water or the emissions of nonferrous smelters (Wezel : n=93, Lommel : n=111, and Pelt : n=133).
In the PheeCad study, in 1991-5, the rural areas (n=609) were re-examined together with an urban control area (Leuven : n=152).
The CadmiBel results showed that after adjustment for sex, age, and body mass index, the 24 h arsenic excretion was on average low in Liege (91 nmol), Charleroi (155 nmol), Hechtel-Eksel (144 nmol), and Wezel (158 nmol), whereas the highest excretions were found in Lommel (570 nmol) and Pelt (373 nmol).
During the PheeCad study, the mean 24 h arsenic excretion in the rural areas ranged from 81 to 111 nmol.
This was lower than six years earlier and similar to the excretion in the control town (108 nmol).
Longitudinal studies in 529 people living in the rural areas confirmed that their 24 h arsenic excretion had decreased (P<0.001) from 222 to 100 nmol.
As well as the drinking water, industry was likely to be a source of the increased exposure in Lommel and Pe...
Mots-clés Pascal : Arsenic, Composé minéral, Polluant, Environnement, Absorption, Urine, Excrétion, Variation géographique, Variation temporelle, Belgique, Europe, Santé et environnement, Zone industrielle, Milieu rural, Etude longitudinale, Homme, Epidémiologie
Mots-clés Pascal anglais : Arsenic, Inorganic compound, Pollutant, Environment, Absorption, Urine, Excretion, Geographical variation, Time variation, Belgium, Europe, Health and environment, Industrial area, Rural environment, Follow up study, Human, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0247370
Code Inist : 002B03M01. Création : 199608.