Dust exposure, respiratory symptoms, and longitudinal decline of lung function in young coal miners.
Objectives-To study the role of dust exposure on incidence of respiratory symptoms and decline of lung function in young coal miners.
Methods-The loss of lung function (forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow (MEF), carbon monoxide transfer factor (TLCO)) with time and the incidence of respiratory symptoms in 909 Sardinian coal miners (followed up between 1983 and 1993 with seven separate surveys) has been compared with the past and current individual exposures to respirable mixed coal dust.
Multiple linear and logistic regression models were used simultaneously controlling for age, smoking, past occupational exposures, and other relevant covariates.
According to the relatively low dust exposures experienced during the follow up few abnormal chest x ray films were detected.
In the cross sectional analysis of initial data, significant associations between individual cumulative exposure to dust, decrements in FEV1 and MEFs, and increasing prevalence of respiratory symptoms were detected after allowing for the covariates included in the model.
The yearly decline of FVC, FEV1, and single breath carbon monoxide transfer factor (TLCO/VA) was still significantly related to the individual exposure to dust experienced during the follow up, even after allowing for age, smoking, initial cumulative exposure to dust, and initial level of each functional variable.
In logistic models, dust exposure was a ...
Mots-clés Pascal : Pneumoconiose, Bronchopneumopathie obstructive, Fonction respiratoire, Exposition professionnelle, Poussière, Mine charbon, Adulte jeune, Homme, Italie, Europe, Médecine travail, Toxicité, Epidémiologie, Etude longitudinale, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Pneumoconiosis, Obstructive pulmonary disease, Lung function, Occupational exposure, Dust, Coal mine, Young adult, Human, Italy, Europe, Occupational medicine, Toxicity, Epidemiology, Follow up study, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0247369
Code Inist : 002B03L03. Création : 199608.