Radium in drinking water and risk of bone cancer in Ontario youths : a second study and combined analysis.
Objectives-Radium induces bone sarcomas at high doses, but there is controversy about risk at low doses.
A previous study in Ontario found an association between the presence of radium in birth-place water supplies and an increased risk of death from bone cancer in young people.
An investigation was performed to test the findings of the previous study with an independent group of subjects for whom complete information on radium exposure would be obtained.
Methods-A population based case-control study (238 cases ; 432 controls) was conducted with incident cases of bone sarcoma identified from the Ontario cancer registry.
Residential histories were collected by questionnaire and water samples were obtained and analysed for radium content.
There was an association between risk of osteosarcoma and birth-place exposures (odds ratios (ORs) and 90% confidence intervals (90% CIs) 1.77 (1.03-3.00) but not with lifetime measures of exposure.
When lifetime exposure was dichotomised, the OR was 1.31 (0.76-2.24) for osteosarcoma.
There was no trend with increasing exposure.
Bootstrap resampling was used to simulate lifetime doses in a pooled analysis of 1293 subjects from the two Ontario studies.
The ORs were 1.38 (1.08-1.73) for all sarcomas, and 1.44 (1.01-1.87) for osteosarcoma.
Geometric mean doses in bone were about 26 mRad.
Conclusions-An association was found between the presence of radium in birth-place water supplies and increased risk of bone sarcoma ...
Mots-clés Pascal : Radium, Contamination, Eau potable, Pollution radioactive, Toxicité, Tumeur maligne, Os, Adulte jeune, Lieu naissance, Epidémiologie, Ontario, Santé et environnement, Homme, Canada, Amérique du Nord, Amérique, Système ostéoarticulaire pathologie
Mots-clés Pascal anglais : Radium, Contamination, Drinking water, Radioactive pollution, Toxicity, Malignant tumor, Bone, Young adult, Birth place, Epidemiology, Ontario, Health and environment, Human, Canada, North America, America, Diseases of the osteoarticular system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0247368
Code Inist : 002B30A02A. Création : 199608.