Blood transfusion as a risk factor for non-Hodgkin lymphoma.
In a case control study of 280 out of 426 consecutive patients with a recent diagnosis of non-Hodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview.
Using an age-and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44).
ORs were also determined for transfusions received in the intervals 1-5,6.15,16-25 and =26 years before diagnosis.
In the interval 6-15 years, the OR for transfusion was 2.83 (95% CI 1.60 4.99) whereas ORs for transfusions received in other intervals were lower and not significantly elevated.
Histological diagnoses (Kiel classification) and results of staging procedures were known for 185 patients.
For low-grade NHL of nodal B-cell chronic lymphocytic leukaemia (B-CLL) or immunocytoma type, the OR for transfusions was 4.15 (95% Cl 1.92-9.01).
For low-grade nodal lymphomas of follicle centre cell type and high-grade nodal lymphomas, no relation to transfusions could be demonstrated.
For high-grade extranodal lymphoma as sole manifestation, OR for transfusions was 3.27 (95%, CI 1.30 8.24).
It is concluded that blood transfusion may be a risk factor for NHLs especially those of B-CLL or immunocytoma type and for high-grade extranodal lymphoma.
Mots-clés Pascal : Lymphome non hodgkinien, Facteur risque, Transfusion, Sang, Epidémiologie, Suède, Europe, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Etude cas témoin
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Risk factor, Transfusion, Blood, Epidemiology, Sweden, Europe, Human, Malignant hemopathy, Lymphoproliferative syndrome, Case control study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0245589
Code Inist : 002B19B. Création : 199608.