Physical activity and risk of colorectal cancer in men and women.
We examined the association between self-reported occupational and recreational physical activity and the subsequent risk of colorectal cancer in a population-based cohort in Norway.
During a mean follow-up time of 16.3 years for males and 15.5 years for females, 236 and 99 colon cancers and 170 and 58 rectal cancers were observed in males and females, respectively, among 53 242 males and 28 274 females who attended the screening between 1972 and 1978.
Physical activity at a level equivalent to walking or bicycling for at least four hours a week during leisure-time was associated with decreased risk of colon cancer among females when compared with the sedentary group (RR=0.62,95% CI 0.40-0.97).
Reduced risk of colon cancer was particularly marked in the proximal colon (RR=0.51,95% CI 0.28-0.93).
This effect was not observed for occupational physical activity alone, probably due to a narrow range of self-reported physical activity at work among females.
However, by combining occupational and recreational physical activity we observed an inverse dose-response effect as increasing total activity significantly reduced colon cancer risk (P for trend=0.04).
Among males 45 years or older at entry to the study, an inverse dose-response effect was observed between total physical activity and colon cancer risk (P for trend=0.04).
We also found in males a stronger preventive effect for physical activity in the proximal as compared to distal colon.
In addition, we fou...
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Facteur risque, Epidémiologie, Exercice physique, Etude cohorte, Norvège, Europe, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Risk factor, Epidemiology, Physical exercise, Cohort study, Norway, Europe, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0245587
Code Inist : 002B13B01. Création : 199608.