Biochemical markers of neurotoxicity. A review of mechanistic studies and applications.
Neurotoxicology presents major challenges to the development of biological markers in accordance to conventional research strategies.
Because of the inaccessibility of the nervous system, one of the proposed alternatives is the study of biochemical signals in peripheral tissues which can easily and ethically be obtained in humans, and which could represent surrogate indicators of equivalent parameters in the nervous tissue.
Considerable scientific support to this approach is provided by the results of recent investigations in major areas of pharmacology and psychobiology.
Studies examining parameters of neurotransmission and second messenger systems in peripheral blood cells, and variations in the peripheral body fluid content of endogenous substances reflecting nervous tissue dysfunction or damage are presented in this paper as examples of efforts toward rational development and validation of novel indicators of nervous system toxicity.
Cholinergic muscarinic receptors and calcium signalling in peripheral blood lymphocytes, myelin basic protein in cerebrospinal fluid, and blood polyamines are discussed as potential surrogate indicators based on the results of in vitro or in vivo animal studies of neurotoxic metals (mercury, triethyltin), pesticides (disulfoton), drugs of abuse (d-fenfluramine) and model epileptogenic compounds (kainic acid).
Data from investigations examining serum prolactin, type B monoamine oxidase (MAO-B) and dopamine bêta-hydroxylase ...
Mots-clés Pascal : Composé chimique, Toxicité, Exposition professionnelle, Homme, Médecine travail, Styrène, Plomb, Manganèse, Métal lourd, Détection, Dépistage, Encéphale, Surveillance biologique, Marqueur biologique, Système nerveux pathologie, Neurotransmission
Mots-clés Pascal anglais : Chemical compound, Toxicity, Occupational exposure, Human, Occupational medicine, Styrene, Lead, Manganese, Heavy metal, Detection, Medical screening, Brain (vertebrata), Biological monitoring, Biological marker, Nervous system diseases, Neurotransmission
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0245469
Code Inist : 002B03L01. Création : 199608.