Although malignant mesothelioma is known to be strongly related to asbestos exposure, its relationship to familial factors is unclear.
We compared reported histories of cancer in first-degree relatives, obtained from telephone interviews with the next-of-kin of 196 patients who had a pathologic diagnosis of mesothelioma, and with those from 511 deceased controls.
Among men exposed to asbestos, we found a statistically significant twofold elevation in the risk of mesothelioma for patients reporting cancer in two or more first-degree relatives.
We found no significant elevation in women or among the small number of men without asbestos exposure.
The next-of-kin of three patients (but no controls) reported a possible mesothelioma in a first-degree relative ; asbestos exposure could not be ruled out in those relatives.
Associations of asbestos with pleural mesothelioma were stronger among men with a reported family history of cancer than men without, although no statistical evidence of an interaction was detected.
These results provide suggestive, but limited, evidence that a family history of cancer may be a risk factor for mesothelioma, or may indicate an increased susceptibility to mesothelioma given asbestos exposure.
Mots-clés Pascal : Mésothéliome malin, Facteur risque, Epidémiologie, Exposition, Amiante, Antécédent, Histoire familiale, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Parenté premier degré
Mots-clés Pascal anglais : Malignant mesothelioma, Risk factor, Epidemiology, Exposure, Asbestos, Antecedent, Family story, United States, North America, America, Human, Malignant tumor, First degree relatives
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0243944
Code Inist : 002B04B. Création : 199608.