Lung cancer was noted to be increased in cigarette smoking miners and nonminers.
Carcinogen particulates deposit differentially in the central, middle, and peripheral zones of the bronchial tree depending on the size of the particle.
The object of this study was to evaluate the incidence of tumors ; their cell types ; and the relationship of particulate size to their position in the bronchial tree.
Tumor position in the bronchial tree was studied for a cohort of 467 uranium miners and 311 nonminers with lung cancer.
An examination of all histologic subtypes showed that the proportion of lung cancers in the central zone was significantly greater in miners than in nonminers presumably due to the deposition of radon decay products attached to the silica dust particles.
The higher percentage of central tumors in the miners was primarily due to the distribution of a greater proportion of squamous cell and small-cell tumors.
The ratio of 0.75 for the central to middle and peripheral location for adenocarcinomas was much lower than for squamous cell and small-cell carcinomas with ratios of 1.4 and 7.3, respectively.
In the mining cohort, there were ten times as many small-cell tumors in the central area as in the middle and peripheral regions, whereas, for the nonminers there were only five times as many centrally located small-cell tumors as middle and peripheral (chi square is 7.0°, P<0.01).
These data suggest that radon may be dep...
Mots-clés Pascal : Carcinome, Bronchopulmonaire, Localisation, Homme, Radon, Poussière, Inhalation, Uranium, Mine, Irradiation ionisante, Epidémiologie, Carcinogène, Exposition professionnelle, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne
Mots-clés Pascal anglais : Carcinoma, Bronchopulmonary, Localization, Human, Radon, Dust, Inhalation, Uranium, Mine, Ionizing irradiation, Epidemiology, Carcinogen, Occupational exposure, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0240183
Code Inist : 002B11A. Création : 199608.