The relationship between smoking exposure and p53 overexpression in colorectal cancer.
Although epidemiological studies of the relationship between cigarette smoking and colorectal cancer risk have been equivocal, a positive association is consistently found for colorectal adenoma development.
We performed an epidemiological study to determine whether p53 protein overexpression, in tumours obtained at the time of resection, is associated with cigarette exposure in colorectal cancer.
A total of 163 colorectal cancer cases and 326 healthy controls responded to a standardised questionnaire on colorectal cancer risk factors including detailed information on their history of cigarette smoking.
All patients'tumours were analysed immunohistochemically for p53 overexpression using an avidin biotin immunoperoxidase procedure and polyclonal anti-p53 antibody CMI.
Comparison of colorectal cases with controls revealed an elevated risk for ex-smokers (OR=1.34,95% CI 0.85-2.12) and current smokers (OR=1.13,95% CI 0.63-2.02) when compared with non-smokers.
No dose-response relationship was found for total pack-years of smoking (trend test : P=0.19).
However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test : P=0.06).
Estimating the individual relative risk of developing a p53-positive tumour relative to controls showed no associations for smoking status or total pack-years of smoking.
However, when p53-negative cases were compared with controls...
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Carcinogenèse, Pathogénie, Epidémiologie, Facteur risque, Gène suppresseur tumeur, Surexpression génique, Tabagisme, Carcinogène, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Gène p53
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Carcinogenesis, Pathogenesis, Epidemiology, Risk factor, Tumor suppressor gene, Gene overexpression, Tobacco smoking, Carcinogen, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, p53 gene
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0239788
Code Inist : 002B13B01. Création : 199608.