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  1. Natural history of reflux eosophagitis : a 10 year follow up of its effect on patient symptomatology and quality of life.

    Article - En anglais

    Background-Although oesophagitis is the most common diagnosis made at upper gastrointestinal endoscopy, data on the longterm outcome of affected patients are sparse.

    Aims-This study assessed the level of reflux symptoms, quality of life, drug consumption, and complications in patients at least 10 years after diagnosis of oesophagitis at one centre.

    Patients-One hundred and fifty two patients with typical reflux symptoms and a first time diagnosis by endoscopy of grade I-III oesophagitis between 1981 and 1984, were followed up using a postal questionnaire and telephone interview.


    Eighteen of 152 patients had died, 33 failed to respond, and 101 replied (mean follow up 11 years, range 121-160 months).

    Over 70% of patients still had heartburn at least daily (32%) or weekly (19%) or required daily acid suppression treatment (20%). Two patients (2%) had developed oesophageal strictures and one had Barrett's oesophagus.

    Two of eight quality of life scores (physical function and social function) measured by the Short Form-36 were significantly lower than Northern Ireland population scores.

    Conclusion-Nearly three quarters of patients previously diagnosed as having oesophagitis still had significant morbidity related to gastro-oesophageal reflux disease more than 10 years after diagnosis.

    Some quality of life scores were significantly lower than those of the general population.

    Mots-clés Pascal : Reflux gastrooesophagien, Exploration clinique, Long terme, Evolution, Symptomatologie, Qualité vie, Consommation, Médicament, Complication, Questionnaire, Résultat, Homme, Appareil digestif pathologie, Oesophage pathologie

    Mots-clés Pascal anglais : Gastroesophageal reflux, Clinical investigation, Long term, Evolution, Symptomatology, Quality of life, Consumption, Drug, Complication, Questionnaire, Result, Human, Digestive diseases, Esophageal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0239051

    Code Inist : 002B13A03. Création : 199608.