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  1. The development, reliability and validity of a disease specific quality of life model for adults with growth hormone deficiency.

    Article - En anglais

    OBJECTIVE Adults with GH deficiency frequently complain of lack of energy, fatigue, social isolation and problems with sexual relationships resulting in a low perceived quality of life.

    Previous studies of quality of life (QOL) in GH deficient adults have involved small numbers of patients and used measures not specifically designed for this patient population.

    We have devised a health related QOL model specifically designed for use in adults with GH deficiency and to assess the impact of future GH replacement therapy.

    DESIGN Six measurements were chosen for inclusion in the model.

    Two were adapted for use after clinical interviews with 12 adult GH deficient patients : the Impact and the Life Fulfilment scales.

    The others were the Nottingham Health Profile, the Hospital Anxiety and Depression Scale, the Self-Esteem Scale and the Mental Fatigue Questionnaire.

    The reliability of the 6 measures was assessed by 2 methods : test re-test correlation and internal consistency (Cronbach's alpha).

    The validity of the Impact and Life Fulfilment scales was assessed by correlation with the other 4 scales.

    PATIENTS Questionnaires were completed by 32 adults with hypothalamic pituitary disorders and GH deficiency (11 male, mean age 35.1 years), with a stimulated maximum serum GH response less than 10 mU/l (mean 2.96).

    Two had previously received GH injections in childhood.

    The questionnaires were also completed by 32 age and sex matched control subjects.

    RESULTS The 6 sc...

    Mots-clés Pascal : Déficit, Homme, Adulte, STH, Fiabilité, Validité, Modèle, Qualité vie, Etude statistique, Evaluation, Quality of Life Scale, Impact scale Jacoby, Life Fulfilment Scale Baker, Hormone adénohypophysaire, Hormone protéine

    Mots-clés Pascal anglais : Deficiency, Human, Adult, STH, Reliability, Validity, Models, Quality of life, Statistical study, Evaluation, Quality of Life Scale, Adenohypophyseal hormone, Protein hormone

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0235452

    Code Inist : 002B30A01A2. Création : 199608.