Information about occurrence of testicular cancer (TC) in relatives of TC patients has been collected using questionnaires from 797 out of 922 consecutive Norwegian and 178 out of 237 Swedish patients with TC seen at the Norwegian Radium Hospital and the University Hospital Lund in Sweden during 1981-91.
Fifty-one Norwegian and five Swedish patients had a relative with confirmed TC.
Thus, 51/922 (5.5%) of the Norwegian and 5/237 (2.1%) of the Swedish patients treated during the time interval investigated were considered to have familial TC.
Thirty-two of the patients had an affected first-degree relative.
Expected numbers of cancers in the relatives were computed from data in the Norwegian and Swedish Cancer Registries.
Standardised incidence ratios (SIRs) were taken as observed numbers of TC/expected numbers of TC in the relatives.
The SIR for brothers was 10.2 (95% confidence interval 6.22-15.77).
SIR for fathers was 4.3 (1.6-9.3) and for sons 5.7 (0.7-23.2).
The point estimate for the risk to brothers in the Norwegian part of the sample to develop TC by the age of 60 was 4.1% (95% CI 1.7. - 6.6%). This study indicates that genetic factors may be of greater importance in TC than previously assumed.
Patients with familial testicular cancer had bilateral tumours more often than sporadic cases (9.8% bilaterality in familial vs 2.8% in sporadic cases, P=0.02).
For patients with seminoma age of onset was lower in familial than in sporadic cases (32.9 vs 37.6 ...
Mots-clés Pascal : Tumeur maligne, Testicule, Facteur risque, Epidémiologie, Etude familiale, Norvège, Europe, Suède, Sud, Homme, Appareil génital mâle pathologie, Testicule pathologie
Mots-clés Pascal anglais : Malignant tumor, Testicle, Risk factor, Epidemiology, Family study, Norway, Europe, Sweden, South, Human, Male genital diseases, Testicular diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0235432
Code Inist : 002B20B02. Création : 199608.