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  1. Occupational IgE-mediated rhinitis caused by ninhydrin.

    Article - En anglais

    Ninhydrin is a laboratory chemical used as a reagent in the detection of free amino and carboxyl groups in proteins and peptides.

    We present the case of a laboratory technician who developed symptoms of rhinitis when handling papers immersed in a solution containing ninhydrin.

    Prick tests for ninhydrin and ninhydrin RAST were positive.

    The inhalation provocation test in an exposure chamber gave an immediate nasal response.

    A positive prick test to ninhydrin, an elevated level of specific IgE antibodies to ninhydrin, and the RAST inhibition test confirmed an IgE-mediated type I allergic reaction.

    We are not aware of any other report of ninhydrin as a cause of IgE-mediated allergy.

    Mots-clés Pascal : Rhinite, Allergie, Toxicité, Exposition professionnelle, Technicien, Laboratoire, Test radioallergosorbent, Inhibition, Prick test, Test cutané, Test provocation, Exploration immunologique, Diagnostic, Etude cas, Finlande, Europe, Adulte, Homme, ORL pathologie, Nez pathologie, Immunopathologie, Maladie professionnelle, Médecine travail, Composé chimique, Indane-1,3-dione(2,2-dihydroxy), Ninhydrine, Chambre exposition

    Mots-clés Pascal anglais : Rhinitis, Allergy, Toxicity, Occupational exposure, Technician, Laboratory, Radioallergosorbent test, Inhibition, Prick test, Skin test, Provocation test, Immunological investigation, Diagnosis, Case study, Finland, Europe, Adult, Human, ENT disease, Nose disease, Immunopathology, Occupational disease, Occupational medicine, Chemical compound

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0233428

    Code Inist : 002B06C02. Création : 199608.