To investigate the HLA class I associations of ankylosing spondylitis (AS) in the white population, with particular reference to HLA-B27 subtypes.
B60 typing was performed in 284 white patients with AS.
Allele frequencies of HLA-B27 and HLA-B60 from 5926 white bone marrow donors were used for comparison.
HLA-B27 subtyping was performed by single strand conformation polymorphism (SSCP) in all HLA-B27 positive AS patients, and 154 HLA-B27 positive ethnically matched blood donors.
The strong association of HLA-B27 and AS was confirmed (odds ratio (OR) 171,95% confidence interval (CI) 135 to 218 ; p<10-99).
The association of HLA-B60 with AS was confirmed in HLA-B27 positive cases (OR 3.6,95% CI 2.1 to 6.3 ; p<5 X 105), and a similar association was demonstrated in HLA-B27 negative AS (OR 3.5,95% CI 1.1 to 11.4 ; p<0.05).
No significant difference was observed in the frequencies of HLA-B27 allelic subtypes in patients and controls (HLA-B*2702, three of 172 patients upsilon five of 154 controls ; HLA-B *2705,169 of 172 patients upsilon 147 of 154 controls ; HLA-B*2708, none of 172 patients upsilon two of 154 controls), and no novel HLA-B27 alleles were detected.
B60 are associated with susceptibility to AS, but differences in HLA-B27 subtype do not affect susceptibility to AS in this white population.
Mots-clés Pascal : Spondylarthrite ankylosante, Système HLA, Facteur risque, Allèle, Caucasoïde, Royaume Uni, Europe, Homme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire
Mots-clés Pascal anglais : Ankylosing spondylitis, HLA-System, Risk factor, Allele, Caucasoid, United Kingdom, Europe, Human, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0232840
Code Inist : 002B15D. Création : 199608.