In the present paper, reports of animal experiments and of epidemiological studies concerning the cardiovascular effects of exposure to carbon disulfide (CS2) are reviewed.
The animal experiments show an atherogenic effect of CS2.
The mortality studies indicate a relative risk of coronary mortality varying from 0.83 to 3.61.
The morbidity studies had, however, considerable different results, the reasons of which are discussed.
Overall the evidence that CS2 is a risk factor for cardiovascular disease seems convincing.
Further research is, however, required to clarify the mechanisms of these effects in humans, whether they are reversible, the geographical differences in morbidity, the exposure-response relationship and the interaction with other cardiovascular risk factors.
International cooperation for longitudinal studies, with well standardized common study designs are suggested.
Mots-clés Pascal : Carbone disulfure, Exposition professionnelle, Mortalité, Morbidité, Homme, Animal, Cellulose régénérée, Industrie, Solvant organique, Appareil circulatoire pathologie, Article synthèse, Médecine travail, Epidémiologie
Mots-clés Pascal anglais : Carbon disulfide, Occupational exposure, Mortality, Morbidity, Human, Animal, Cellulose hydrate, Industry, Organic solvent, Cardiovascular disease, Review, Occupational medicine, Epidemiology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0229405
Code Inist : 002B03L06. Création : 199608.