Lung cancer incidence is gradually leveling off in U.S. men but is continuing to rise in U.S. women.
This increase in U.S. women exceeds that expected from a slower decline of smoking among women.
Recent epidemiologic and biochemical studies suggest gender differences in susceptibility to tobacco carcinogens.
We conducted an up-to-date, more in-depth evaluation of our earlier observation of a potential gender difference in relative risk (RR) of lung cancer due to smoking.
We added information from several additional case and control subjects and included more precise histologic classification of the cancer type, accurate quantitation of smoke exposure, and adjustments for body size.
The present investigation was a part of an ongoing hospital-based, case-control study by the American Health Foundation.
It included data from 1889 case subjects (1108 males and 781 females) with lung cancer of squamous/epidermoid, small-cell/oat cell, large-cell, and adenocarcinoma types and 2070 control subjects (1122 males and 948 females) with diseases unrelated to smoking.
The case and control subjects were admitted to participating hospitals from 1981 to 1994 and were pair-matched by age, sex, hospital, and the time of hospital admission.
Ex-smokers and non-Caucasians were excluded from analyses to avoid confounding.
The RRs and 95% confidence intervals were estimated from adjusted odds ratios (ORs) by use of unconditional multiple logisti...
Mots-clés Pascal : Carcinome, Adénocarcinome, Bronchopulmonaire, Epidémiologie, Homme, Analyse risque, Sexe, Carcinogène, Tabagisme, Sensibilité, Mâle, Femelle, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne
Mots-clés Pascal anglais : Carcinoma, Adenocarcinoma, Bronchopulmonary, Epidemiology, Human, Risk analysis, Sex, Carcinogen, Tobacco smoking, Sensitivity, Male, Female, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0229034
Code Inist : 002B11A. Création : 199608.